丹参酮Ⅱ

A

是丹参（Salvia miltiorrhiza Bunge）中含量较高的一种有效成分

[1]

，系为酯溶性成分。经磺化后成为水溶性化合物，可作静脉给药，治疗冠心病等

[2]

。

为探讨丹参酮Ⅱ

A

磺酸钠在体内的作用原理，我们用

3

H-丹参酮Ⅱ

A

磺酸钠在大鼠体内进行分布、排泄和代谢的研究。

3

H-tanshinone II-A sulphonate was given to rats intravenously. The distribution of radioactivity was the highest in liver

then spleen

kidneys and lungs

and each reached its maximum in 2 hr. after injection. The biological half-lives (t

1/2

alpha and t

1/2

beta) were 27 and 199 min respectively. Within 72 hr.

the activity was excreted 18%in the urine and 75% in the feces. By thin-layer chromatography and autoradiography of bile

urine and feces 3 spots of metabolites were found.