Percutaneous absorption and autoradiography of [2-<sup>14</sup>C] carbendazol in rats

Hesheng Shao; Shangren Pan; Xinan Jing; Weiyi Li; Lanqin Yin; Yingying Feng

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Percutaneous absorption and autoradiography of [2-¹⁴C] carbendazol in rats

更新时间：2022-08-16

- Percutaneous absorption and autoradiography of [2-¹⁴C] carbendazol in rats
- Nuclear Techniques Vol. 11, Issue 8, (1988)
- 作者机构：
  
  江苏省原子医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：09 May 1987，
  
  Published：1988-08
- 稿件说明：
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Hesheng Shao, Shangren Pan, Xinan Jing, et al. Percutaneous absorption and autoradiography of [2-¹⁴C] carbendazol in rats[J]. Nuclear techniques, 1988, 11(8): 56-59.
DOI：

Hesheng Shao, Shangren Pan, Xinan Jing, et al. Percutaneous absorption and autoradiography of [2-¹⁴C] carbendazol in rats[J]. Nuclear techniques, 1988, 11(8): 56-59. DOI：

摘要

用示踪及放射自显影技术研究了多菌灵的软膏和溶液在大鼠的透皮吸收，作用部位及其在皮肤中的分布。表明多菌灵软膏透入背部皮肤为5.7%，透皮常数为1.86×10

-6

cm/h；多菌灵溶液透入尾部皮肤为9.8%，透皮常数为29.3×10

-6

cm/h。该药透皮吸收主要在角质层，作用只局限于渗透部位。

Abstract

This paper reported the results of skin absorption and distribution of unguent and solution of [2-

C] carbendazol (MBC) in rats by using radioactive tracer and autoradiography. It was concluded as: 1) the percentage permeated into skin for unguent was 5.7%

while for solution 9.8%; 2) permeability constant for unguent was 1.86×10

-6

cm/h

while for solution 29.3×10

-6

cm/h; 3) carbendazol remained mainly in stratum corneum.

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Keywords

references

R. W．马什主编，郑仲等译，内吸性杀菌剂，北京，化学工业出版社，第1版， 1983 年，第85页。

张文娟等，临床皮肤科杂志， 12 （ 1983 ）， 4 ： 180 。

柳翠敬，药学通报， 17 （ 1982 ）， 3 ： 39 。

R. T. Tregear , Physical functions of skin , Academic Press , London , 1966 , p. 1 .

K. Mimura and S. Baba , Radioisotopes , 32 （ 1983 ）, 7 .

中山医学院主编，病理学上册，第1版，北京，人民卫生出版社， 1978 年，第638页。

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Percutaneous absorption and autoradiography of [2-14C] carbendazol in rats

DOI：

摘要

Abstract

关键词

Keywords

references

Percutaneous absorption and autoradiography of [2-¹⁴C] carbendazol in rats