Targeting Hela cancer cells with avidin-dendrimer

XU Xiaoping1; 2 ZHANG Yuanqing1; 2 SHEN Yumei1 1

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Targeting Hela cancer cells with avidin-dendrimer

更新时间：2021-03-05

- Targeting Hela cancer cells with avidin-dendrimer
- NUCLEAR TECHNIQUES Vol. 34, Issue 4, (2011)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所
  2. 中国科学院研究生院
- 作者简介：
- 基金信息：
  
  中国科学院“百人计划”(No.26200601)资助
- DOI：
  CLC： R730.5
- Published：01 April 2011
- 稿件说明：
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[1]许晓平,张元庆,沈玉梅.Avidin-dendrimer对Hela细胞的靶向研究[J].核技术,2011,34(04):293-298.

XU Xiaoping1, 2 ZHANG Yuanqing1, 2 SHEN Yumei1 1. Targeting Hela cancer cells with avidin-dendrimer[J]. Nuclear techniques, 2011, 34(4): 293-298.
[1]许晓平,张元庆,沈玉梅.Avidin-dendrimer对Hela细胞的靶向研究[J].核技术,2011,34(04):293-298. DOI：

XU Xiaoping1, 2 ZHANG Yuanqing1, 2 SHEN Yumei1 1. Targeting Hela cancer cells with avidin-dendrimer[J]. Nuclear techniques, 2011, 34(4): 293-298. DOI：

摘要

树状大分子对肿瘤有显著的EPR效应

本文在5代聚酰胺-胺类树状大分子表面连接对肿瘤有主动靶向作用的抗生物素蛋白（亲和素）

然后用放射性同位素99mTc标记这种兼具被动靶向与主动靶向作用的纳米粒子。Hela细胞体外摄取实验表明连接靶向分子亲和素（Avidin）的Biotin-PAMAM G5-1B4M-99mTc纳米复合物对Hela细胞的摄取远高于未连接靶向分子Avidin的同类纳米粒子。如进一步在小鼠SPECT成像试验中表现出良好的显像效果

这种同位素标记的纳米粒子将有望用于肿瘤的早期诊断或治疗。

Abstract

Dendrimers can target tumor taking advantage of enhanced permeation and retention effect(EPR).In this study

partially acetylated generation 5(G5) polyamidoamine(PAMAM) dendrimer was conjugated with the active targeting moiety(avidin).The nanoparticles which have passive and active tumor-targeting were radiolabel with 99mTc.The nano-particle conjugated with avidin(avidin-G5-1B4M-99mTc) exhibited much higher cellular uptake into Hela cells than those without avidin conjugate.Using this conjugate

excellent SPECT imaging results were obtained in tumor-bearing nude.This radiolabelling nano-particle has the potential of early stage cancer diagnosis

and cancer therapy.

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上海交通大学系统生物医学研究院系统生物医学教育部重点实验室

Nanfang Hospital, First Military Medical University

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