A study on carrier-free <sup>188</sup>Re labelled norfloxacin

ZHANG Xiuli  WANG Yongxian  ZHANG Chunfu  LI Junling  YIN Duanzhi

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A study on carrier-free ¹⁸⁸Re labelled norfloxacin

更新时间：2021-03-12

- A study on carrier-free ¹⁸⁸Re labelled norfloxacin
- NUCLEAR TECHNIQUES Issue 2, (2003)
- 作者机构：
  
  1. 中国科学院上海原子核研究所
  2. 中国科学院上海原子核研究所,上海,201800
- 作者简介：
- 基金信息：
  
  中国科学院知识创新工程重大项目资助(KJCX1-SW-08)
- DOI：
  CLC： R817
- Published：01 February 2003
- 稿件说明：
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[1]张秀利,汪勇先,张春富,李俊玲,尹端沚.无载体~(188)Re标记氟哌酸的研究[J].核技术,2003(02):156-158.

ZHANG Xiuli WANG Yongxian ZHANG Chunfu LI Junling YIN Duanzhi. A study on carrier-free ¹⁸⁸Re labelled norfloxacin[J]. Nuclear techniques, 2003, (2): 156-158.
[1]张秀利,汪勇先,张春富,李俊玲,尹端沚.无载体~(188)Re标记氟哌酸的研究[J].核技术,2003(02):156-158. DOI：

ZHANG Xiuli WANG Yongxian ZHANG Chunfu LI Junling YIN Duanzhi. A study on carrier-free ¹⁸⁸Re labelled norfloxacin[J]. Nuclear techniques, 2003, (2): 156-158. DOI：

摘要

用188W/188Re发生器得到的188Re研制了具有潜在临床应用价值的188Re标记的氟哌酸（188Re-Norfloxacin）。研究了在无载体的条件下

pH值、温度、时间、氯化亚锡含量对标记率的影响

确定了最佳标记条件。实验结果表明:用无载体188Re标记的188Re-Norfloxacin的标记率为92%以上

标记后调pH为4

24h后

放化纯度基本不变。

Abstract

Synthesis of the carrier free 188Re-norfloxacin was investigated using 188Re eluted from a 188W/188Re gen-erator. Stannous chloride was used as the reducing agent for the reduction of the carrier free 188Re. Influences of concentration of reducing agent

temperature and reaction time on the labelling yield of 188Re-norfloxacin were examined and the optimum conditions were obtained. Under the optimum conditions

the labelling yield of 188Re-norfloxacin was more than 92%. The stability of 188Re-norfloxacin at pH 4 was studied. Radiochemical purity of 188Re-norfloxacin was nearly constant in 24 hours.

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A study on carrier-free 188Re labelled norfloxacin

DOI：

摘要

Abstract

关键词

Keywords

references

A study on carrier-free ¹⁸⁸Re labelled norfloxacin