Preparation of <sup>99</sup>Tc<sup>m</sup>-CLP imaging probe of lung carcinoma

QIANG Yonggang LIAO Yonghua

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Preparation of ⁹⁹Tc^m-CLP imaging probe of lung carcinoma

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- Preparation of ⁹⁹Tc^m-CLP imaging probe of lung carcinoma
- NUCLEAR TECHNIQUES Issue 8, (2004)
- 作者机构：
  
  1. 广州医学院实验核医学教研室
  2. 广州医学院实验核医学教研室,广州,510182
- 作者简介：
- 基金信息：
  
  广东省医药卫生科研基金项目(A2001482)资助
- DOI：
  CLC： R734.2
- Published：01 August 2004
- 稿件说明：
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[1]强永刚,廖永华.~(99)Tc~m-CLP肺肿瘤显像探针的制备[J].核技术,2004(08):608-611.

QIANG Yonggang LIAO Yonghua. Preparation of ⁹⁹Tc^m-CLP imaging probe of lung carcinoma[J]. Nuclear techniques, 2004, (8): 608-611.
[1]强永刚,廖永华.~(99)Tc~m-CLP肺肿瘤显像探针的制备[J].核技术,2004(08):608-611. DOI：

QIANG Yonggang LIAO Yonghua. Preparation of ⁹⁹Tc^m-CLP imaging probe of lung carcinoma[J]. Nuclear techniques, 2004, (8): 608-611. DOI：

摘要

从牛鼻软骨中获取HA-CLP复合物

4mol/L盐酸胍解离和亲和层析法纯化CLP。然后用SnCl2活化CLP后进行99Tcm离子螯合标记

获得了肺肿瘤显像探针99Tcm-CLP。结果显示:99Tcm-CLP的标记率和放射化学纯度均达到90％以上

体外与HA的亲和力KA为1.12×109L/mol

将99Tcm-CLP注入肺腺癌裸鼠体内发现在瘤区与HA有较好的浓集。表明99Tcm-CLP标记探针可用于肺肿瘤的显像研究。

Abstract

The process of preparing an imaging micro-probe 99Tcm-CLP from bovine nose cartilage is described in detail. Both labeled rate and radiochemical purity of 99Tcm-CLP are greater than 90%

and KA is 1.12 × 109L/mol in vitro. After the Balb/c nu/nu mice with lung cancer were intravenously injected by the 99Tcm-CLP

the radioactivity was found to be well concentrated at the lung-cancer region

which suggests that the 99Tcm-CLP micro-probe can be used in imaging study of desmohemoblast on lung carcinoma.

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Preparation of 99Tcm-CLP imaging probe of lung carcinoma

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摘要

Abstract

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references

Preparation of ⁹⁹Tc^m-CLP imaging probe of lung carcinoma