Study on chromosome aberration in human peripheral blood lymphocytes induced by 188ReO4- in vitro

DONG Mo  LI Huiyuan  WU Yuanfang

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Study on chromosome aberration in human peripheral blood lymphocytes induced by ¹⁸⁸ReO₄^- in vitro

更新时间：2021-03-12

- Study on chromosome aberration in human peripheral blood lymphocytes induced by ¹⁸⁸ReO₄^- in vitro
- NUCLEAR TECHNIQUES Issue 11, (2001)
- 作者机构：
  
  1. 中国科学院上海原子核研究所
  2. 上海市放射医学研究所
  4. ,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  CLC： R818
- Published：01 November 2001
- 稿件说明：
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[1]董墨,李惠源,吴元芳,邵松生,林雅萍,邹美君,刘红珍.~(188)Re诱发人离体外周血淋巴细胞染色体畸变的初步研究[J].核技术,2001(11):915-919.

DONG Mo LI Huiyuan WU Yuanfang. Study on chromosome aberration in human peripheral blood lymphocytes induced by ¹⁸⁸ReO₄^- in vitro[J]. Nuclear techniques, 2001, (11): 915-919.
[1]董墨,李惠源,吴元芳,邵松生,林雅萍,邹美君,刘红珍.~(188)Re诱发人离体外周血淋巴细胞染色体畸变的初步研究[J].核技术,2001(11):915-919. DOI：

DONG Mo LI Huiyuan WU Yuanfang. Study on chromosome aberration in human peripheral blood lymphocytes induced by ¹⁸⁸ReO₄^- in vitro[J]. Nuclear techniques, 2001, (11): 915-919. DOI：

摘要

将人离体外周血在不同剂量的188ReO- 4中培养 5 4h

观察淋巴细胞有丝分裂中期的染色体型和单体型畸变

这两种类型的畸变均有随188Re活度的增高而增加的趋势

并与活度存在一定的依赖关系

染色体畸变以二次多项式的模式为佳。单体型畸变、畸变细胞、染色体断片也可配以直线回归。

Abstract

Human peripheral blood exposed to 188 ReO - 4 at various doses for 54h was examined to observe the chromosome and chromatin aberrations at metaphases during mitosis of lymphocytes. The findings indicate that there was a tendency of increased aberration in both types with increasing 188 ReO - 4 concentration and a dose dependency can be seen. The aberration yield is best fitted by the quadratic model. Chromatin aberrations

aberrations cell and chromosome fragments are also fitted by a linear-regression model.

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