DNA strand breakage of human hepatoma cells induced by γ-ray   measured using the Comet Assay

WANG Jufang  HE Jing  ZHOU Guangming  LI Wenjian  WEI Zengquan

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DNA strand breakage of human hepatoma cells induced by γ-ray measured using the Comet Assay

更新时间：2021-03-12

- DNA strand breakage of human hepatoma cells induced by γ-ray measured using the Comet Assay
- NUCLEAR TECHNIQUES Issue 11, (2001)
- 作者机构：
  
  1. 中国科学院近代物理研究所
  2. 兰州大学,兰州,730000
- 作者简介：
- 基金信息：
  
  中国科学院“西部之光”资助项目 (XB980 6 0 4)
- DOI：
  CLC： R735.7
- Published：01 November 2001
- 稿件说明：
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[1]王菊芳,何静,周光明,李文建,卫增泉,高清祥.彗星分析法检测γ射线诱导的人肝癌细胞DNA链断裂[J].核技术,2001(11):895-898.

WANG Jufang HE Jing ZHOU Guangming LI Wenjian WEI Zengquan. DNA strand breakage of human hepatoma cells induced by γ-ray measured using the Comet Assay[J]. Nuclear techniques, 2001, (11): 895-898.
[1]王菊芳,何静,周光明,李文建,卫增泉,高清祥.彗星分析法检测γ射线诱导的人肝癌细胞DNA链断裂[J].核技术,2001(11):895-898. DOI：

WANG Jufang HE Jing ZHOU Guangming LI Wenjian WEI Zengquan. DNA strand breakage of human hepatoma cells induced by γ-ray measured using the Comet Assay[J]. Nuclear techniques, 2001, (11): 895-898. DOI：

摘要

以人肝癌SMMC - 772 1细胞为材料

用彗星分析法研究了γ射线诱导的DNA链断裂

结果表明

随着剂量的增加

彗尾逐渐变长

彗尾的细胞数也越来越多 ;彗尾与彗头的长度比和面积比与剂量成线性正相关

尤以长度比随剂量的增加变化为明显

可反映γ射线诱导的DNA链断裂程度。

Abstract

In this paper

DNA strand breakage induced by γ-ray was studied using the Comet Assay. The human hepatoma cells were chosen as the test cell line. The results showed that the length of the tail appeared longer as the dose increased

and the number of cells with tail

increased with increasing dose. The length ratio and area ratio had positive correlation with the dose. Among them

the length ratio showed more obvious change with the increasing dose than area ratio

thus it could be used to describe the level of DNA strand breakage simply and efficiently.

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