A kit for preparation of   <sup>188</sup>Re sulfide suspension

YU Junfeng  YIN Duanzhi  CUI Haiyan  XU Jianying  ZHANG Lei  ZHOU Wei    MIN Xiaofeng  CHEN Minfeng  TAN Mingguang  WANG Yongxian

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A kit for preparation of ¹⁸⁸Re sulfide suspension

更新时间：2021-03-12

- A kit for preparation of ¹⁸⁸Re sulfide suspension
- NUCLEAR TECHNIQUES Issue 11, (2001)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
  
  国家医药新药基金 (96 - 90 1- 85 - 15 3)
- DOI：
  CLC： R817.5
- Published：01 November 2001
- 稿件说明：
移动端阅览
[1]于俊峰,尹端沚,崔海燕,须剑鹰,张蕾,周伟,闵小锋,陈敏锋,谈明光,汪勇先.~(188)Re-硫化铼混悬液药盒的研制[J].核技术,2001(11):929-932.

YU Junfeng YIN Duanzhi CUI Haiyan XU Jianying ZHANG Lei ZHOU Wei MIN Xiaofeng CHEN Minfeng TAN Mingguang WANG Yongxian. A kit for preparation of ¹⁸⁸Re sulfide suspension[J]. Nuclear techniques, 2001, (11): 929-932.
[1]于俊峰,尹端沚,崔海燕,须剑鹰,张蕾,周伟,闵小锋,陈敏锋,谈明光,汪勇先.~(188)Re-硫化铼混悬液药盒的研制[J].核技术,2001(11):929-932. DOI：

YU Junfeng YIN Duanzhi CUI Haiyan XU Jianying ZHANG Lei ZHOU Wei MIN Xiaofeng CHEN Minfeng TAN Mingguang WANG Yongxian. A kit for preparation of ¹⁸⁸Re sulfide suspension[J]. Nuclear techniques, 2001, (11): 929-932. DOI：

摘要

研制了一种药盒

能简单、快速、有效地制备188Re -硫化铼混悬液制剂。药盒由A、B、C 3瓶（10mL/瓶）组成

在无菌环境下

配制各种试剂。A瓶加入mol比为 70 :1的Na2 S2 O3 和KReO4溶液 1mL

再加入一定量的赋形剂 ;B瓶加入 5mol/L的盐酸溶液 1mL ;C瓶加入摩尔比为 10 0 0 :1的PVP和NaOH溶液 1.5mL。B瓶加盖密封 ;A瓶和C瓶在冷冻干燥后

压盖密封。无菌、细菌内毒素及安全性检验均合格。常温下放置

制备188Re -硫化铼混悬液

在两个月内始终保持很高的标记率（>98% ）

颗粒度为 1— 5 μm（6 0 .1± 12 .7） % ;5— 10 μm（30 .9± 8.1） % ;>10 μm（9.0±4 .7） %。制备的188Re -硫化铼混悬液在 5天内非常稳定

放化纯度 >98%

颗粒度为 1— 5 μm（49.9± 4 .4 ） % ;5— 10 μm（41.1± 5 .4 ） % ;>10 μm（9.0± 3.3） %。

Abstract

The 188 Re sulfide suspension could be prepared quickly by a kit. The kit consists of three 10mL vials. All the procedures were carried out in sterility circumstance. Vial A consisted of 1mL KReO 4 and Na 2S 2O 3 (mole ratio 1:70) solution with excipient. Vial B was 5mol/L HCl solution. Vial C consisted of 1.5mL PVP and NaOH solution (mole ratio 1000:1). Vial B was sealed

Vial A and C were freeze-dried. Bacterium check

endotoxin check and security check were qualified. Kits were kept at ambieut temperature and the Labelling efficiency of 188 Re sulfide suspension was more than 98% with 2 months. The particle sizes were 1-5μm (60.1±12.7)%; 5-10μm(30.9±8.1)%; >10μm(9.0±4.7)%. The radiochemical purity of 188 Re sulfide suspension made by the kit was higher than 98% in 5 days with particle sizes 1-5μm(49.9±4.4%); 5-10μm(41.1±5.4)%; >10μm(9.0±3.3)%.

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Related Institution

Chongqing University of Medical Sciences

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Institute for Drus and Biological Products Control of the Health Ministry

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A kit for preparation of 188Re sulfide suspension

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摘要

Abstract

关键词

Keywords

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A kit for preparation of ¹⁸⁸Re sulfide suspension