Automated synthesis of <sup>18</sup>F-fluoroacetate as tumor imaging agent

TANG Ganghua1 TANG Xiaolan2 WANG Mingfang1 LUO Lei1 GAN Manquan1 1

doi:null

您当前的位置：

首页 >

文章列表页 >

Automated synthesis of ¹⁸F-fluoroacetate as tumor imaging agent

更新时间：2021-03-12

- Automated synthesis of ¹⁸F-fluoroacetate as tumor imaging agent
- NUCLEAR TECHNIQUES Issue 1, (2006)
- 作者机构：
  
  1. 南方医科大学南方医院核医学科PET中心
  2. 华南农业大学理学院
  3. 南方医科大学南方医院核医学科PET中心,广州,510515
  4. ,广州,510642
- 作者简介：
- 基金信息：
  
  广东省科技计划资助项目(2003C34304);南方医科大学南方医院院长基金资助项目(991015)
- DOI：
  CLC： R817
- Published：01 January 2006
- 稿件说明：
移动端阅览
[1]唐刚华,唐小兰,王明芳,罗磊,甘满权.肿瘤显像剂~(18)F-氟代乙酸盐的自动化合成[J].核技术,2006(01):59-62.

TANG Ganghua1 TANG Xiaolan2 WANG Mingfang1 LUO Lei1 GAN Manquan1 1. Automated synthesis of ¹⁸F-fluoroacetate as tumor imaging agent[J]. Nuclear techniques, 2006, (1): 59-62.
[1]唐刚华,唐小兰,王明芳,罗磊,甘满权.肿瘤显像剂~(18)F-氟代乙酸盐的自动化合成[J].核技术,2006(01):59-62. DOI：

TANG Ganghua1 TANG Xiaolan2 WANG Mingfang1 LUO Lei1 GAN Manquan1 1. Automated synthesis of ¹⁸F-fluoroacetate as tumor imaging agent[J]. Nuclear techniques, 2006, (1): 59-62. DOI：

摘要

为研究肿瘤显像剂18F-氟代乙酸盐（18F-FAC）的自动化合成工艺

采用“一锅法”和TRACERlabFXF-N自动化合成装置

以溴代乙酸苄酯为前体

在同一反应瓶中经亲核氟化、NaOH水解两步反应及HPLC系统分离纯化制备18F-FAC注射液。总合成时间约50min

未校正放化产率和放化纯度分别大于45%和99%。采用“一锅法”自动化合成18F-FAC

操作简便

能满足科研和临床正电子发射断层显像的需要。

Abstract

To improve the automated synthesis technology of 18F-fluoroacetate (18F-FAC) as tumor imaging agent

the one-pot procedure at TRACERlab FXF-N module was tried. 18F-FAC injection was obtained via a two-step reaction including nucleophilic fluorination of the precursor benzyl bromoacetate with 18F-fluoride and subsequent hydrolysis of the protecting group with 3 mol/L NaOH at the same reaction vessel

and purification with HPLC system. 18F-FAC was automatically synthesized with an uncorrected radiochemical yield of more than 45% and radiochemical purity of more than 99% in the synthesis process of about 50 min. 18F-FAC injection is easy to be obtained and can be used for clinical and scientific study with positron emission tomography (PET) imaging.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Automated synthesis of ¹⁸F-fluoroacetate via on-column hydrolysis

Automated synthesis of 3’-deoxy-3’-[¹⁸F]fluorothymidine and O-(2-¹⁸F-fluoroethyl)-L-tyrosine as tumor imaging agents

Simple and rapid synthesis of tumor imaging agents¹⁸F-FAC and ¹⁸F- FMISO

Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module

Automated synthesis of novel cell death imaging tracer 18F-FPDuramycin

Related Author

王明芳

唐小兰

TANG Ganghua1 TANG Xiaolan2 WANG Mingfang1 LI Baoyuan1 LIANG Mingquan1 WANG Quanshi1 1

李葆元

梁明泉

王全师

梁明泉

TANG Ganghua1

Related Institution

PET Centre,Department of Nuclear Medicine,Nan Fang Hospital,Southern Medical University,Guangzhou 510515,China) 2

PET Center, Department of Nuclear Medicine, Nan Fang Hospital, Southern Medical University, Guangzhou 510515, China) 2

中山大学附属第一医院核医学科PET-CT中心

PET Centre, Department of Nuclear Medicine, Nan Fang Hospital, Southern Medical University

Department of Nuclear Medicine, The People's Liberation Army(PLA) General Hospital

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：881139 Visits Today：666

⁰

Automated synthesis of 18F-fluoroacetate as tumor imaging agent

DOI：

摘要

Abstract

关键词

Keywords

references

Automated synthesis of ¹⁸F-fluoroacetate as tumor imaging agent