Studies on syntheses and applications of widely used <sup>18</sup>F-labeled intermediates

WANG Mingwei YIN Duanzhi WANG Yongxian

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Studies on syntheses and applications of widely used ¹⁸F-labeled intermediates

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- Studies on syntheses and applications of widely used ¹⁸F-labeled intermediates
- NUCLEAR TECHNIQUES Issue 1, (2006)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所放射性药物研究中心
  2. 中国科学院上海应用物理研究所放射性药物研究中心,上海,201800
- 作者简介：
- 基金信息：
  
  国家自然科学基金(30371634);中国科学院知识创新工程重大项目(KJCX1-SW-08)资助
- DOI：
  CLC： O615
- Published：01 January 2006
- 稿件说明：
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[1]王明伟,尹端沚,汪勇先.常用~(18)F标记中间体的合成及其应用研究[J].核技术,2006(01):63-71.

WANG Mingwei YIN Duanzhi WANG Yongxian. Studies on syntheses and applications of widely used ¹⁸F-labeled intermediates[J]. Nuclear techniques, 2006, (1): 63-71.
[1]王明伟,尹端沚,汪勇先.常用~(18)F标记中间体的合成及其应用研究[J].核技术,2006(01):63-71. DOI：

WANG Mingwei YIN Duanzhi WANG Yongxian. Studies on syntheses and applications of widely used ¹⁸F-labeled intermediates[J]. Nuclear techniques, 2006, (1): 63-71. DOI：

摘要

通过亲核放射氟化标记法

正电子核素[18F]氟被引入到目标分子中有两种途径:直接亲核放射氟化标记和间接亲核放射氟化标记。后者的关键是选择合适的标记中间体。本文根据18F–的取代位置

介绍了两大类、数十种标记中间体的合成及其在放射性药物合成领域中的应用。

Abstract

The positron-emitting nuclide fluorine-18 is of great importance to modern nuclear medicine with the increasing clinic demands of positron emission tomography (PET) and R&D of PET radiopharmaceuticals worldwide. Fluorine-18 can be introduced into a target molecule to prepare the corresponding 18F-labeled radiopharmaceuticals through direct and indirect radiofluorinations. However

it is not suitable for the preparation of biomacromolecular-oriented radiopharmaceuticals such as peptides and protein using the direct labeling methods because of the lack of reaction selectivity. Thus

it is necessary to choose an appropriate 18F-labeled intermediate for the indirect labeling methods. According to the classification of precursors displaced by 18F

this paper briefly introduces two species of 18F-labeled intermediates originated from aliphatic and aromatic displacements and their syntheses and applications in PET radiopharmaceutical domain.

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Related Author

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中国科学院研究生院

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Radiopharmaceutical Centre, Shanghai Institute of Applied Physics, the Chinese Academy of Sciences

中国科学院上海应用物理研究所放药中心

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Studies on syntheses and applications of widely used 18F-labeled intermediates

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摘要

Abstract

关键词

Keywords

references

Studies on syntheses and applications of widely used ¹⁸F-labeled intermediates