Background: With the development of nuclear technology

radionuclides are widely used in every walk of life

such as reactor

radiation breeding

radiopharmaceutical imaging diagnosis and therapy of disease

etc. While application of radioactive material becomes broader

the possibility of radioactive accident becomes higher. Purpose: In order to effectively treat and timely control the radioactive accident

effective protection therapies are indispensable. Fundamental measure that controls internal exposure is mainly accelerated by reducing absorption and elimination of radionuclides in the body

that is

to look for a suitable suction blocking agent or a radionuclide chelating agent. Methods: We modified fullerenes

and a new chelating agent(fullerene macrocyclic polyamine derivatives

CB) was synthesized via the introduction of Nitrogen-containing Heterocyclic functional perssad onto the surface of fullerene. Improved Karber method was applied

and LD50 of the compound was obtained. On the base of toxicity experiment

excretion promotion of CB to uranium was explored through the establishment of a mouse model of infection uranium. Results: The experimental results shown that the median lethal dose of CB was 1.767 mg

and CB could not change the bio-distribution of uranium significantly in mice. CB could reduce the accumulation of uranium in liver and bone in mice obviously

as compared with positive control group Diethylene triamine penlaacetic acid(DTPA) and blank control group. Conclusion: Our analyses suggest that CB possesses the potential chelating agent of U in mice.