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1. 上海交通大学附属第六人民医院
2. 上海交通大学附属第六人民医院,上海,200233
纸质出版日期:2003-11-01
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[1]余永利,朱瑞森,陆汉魁.~(131)I治疗分化型甲状腺癌肝转移[J].核技术,2003(11):868-870.
YU Yongli ZHURuisen LU Hankui. 131I treatment of liver metastases of differentiated thyroid cancer[J]. Nuclear techniques, 2003, (11): 868-870.
对5例分化型甲状腺癌(DTC)肝转移患者进行了131I治疗后随访。结果表明:(1)经131I治疗后生存期2-9年
2001年底随访时均存活。(2)1例在131I治疗11次(44.77 GBq)后131I扫描和B超示肝转移灶消失。(3)甲状腺双侧全切者
131I清除术后剩余甲状腺平均次数3.0次
平均总清除剂量14.58 GBq;而单侧切除者
平均清除次数3.7次
平均总清除剂量20.24 GBq
明显高于前者(P<0.05)。(4)131I首次剂量低于3.7 GBq者
清除术后剩余甲状腺平均次数5.5次
平均总清除剂量28.27 GBq;而首次剂量3.7 GBq者
平均清除次数2.0次
平均总清除剂量11.10 GBq
差异非常显著(P<0.01)。提示术后131I治疗有可能控制病情发展、局限转移灶、提高生活质量和延长生存期。
5 cases of liver metastases of differentiated thyroid cancer (DTC) were given follow-up after 131I therapy. The results were evaluated with clinical appearence
blood examination
radionuclide imaging and survival analysis. The results showed that (1) all cases had survived for 2-9 years in follow-up period; (2) liver metastastic lesion was disappeared after taking 44.77 GBq 131I
as demonstrated by 131I scan and ultrasonic imaging; (3) the sequences and doses of 131I for normal ablation were significantly decreased with total thyroidectomy than with partial-thyroidectomy(P<0.05); (4) the sequences and doses of 131I for normal ablation were significantly decreased with 3.7 GBq initial 131I doses than with <3.7GBq (PO.01). The treatment of 131I with liver metastases from DTC may improve clinical symptoms
raise life quality
reduce lesion size
and prolong life survival.
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