To evaluate the clinical usefulness of 18F-FDG coincidence imaging in detecting tumors and metastases

87 patients with suspected malignant or recurrent tumors were studied. 259-298MBq I8F-FDG was injected

then 40 -60 min after injection the patients underwent I8F-FDG coincidence imaging using GE HAWKEYE Coincidence SPECT in supine position. After reconstruction using iterative algorithm

we obtained the transaxial

coronal and sagittal sections with X-ray attenuation correction. The images were interpreted visually

and also analyzed with operative

histological

CT/MRI and follow-up studies. There were 61 positives

including 5 false-positives and 56 true-positives; 26 negatives

including 2 false-negatives and 24 true-negatives in altogether 87 patients. 136 lesions were detected by 18F-FDG coincidence imaging

including 41 lymph node and remote metastases. In all patients with suspected malignant tumors

the sensitivity

specificity

positive predictive values

negative predictive values and accuracy of 18FHFDG coincidence imaging were 96.6% (56/58)

82.8% (24/29)

91.8% (56/61)

92.8% (24/26) and 92.0% (80/87) respectively. 18F-FDG coincidence imaging had high sensitivity and specificity in tumor diagnosis

and had unique advantages in ascertaining tumor’s nature and in detecting recurrence or metastases

and it was also a valuable diagnostic and investigative method for patients with cancer.