N-Decanoylmorpholine has been used as novel extractant for HNO 3 and U(Ⅵ) in benzene from aqueous nitric acid medium for the first time. The dependence of extraction distribution ratio on the concentration of aqueous nitric acid and extractant was discussed. The extraction mechanisms of HNO 3 and U(Ⅵ) were confirmed. DMPHL was found suitable for extraction of U(Ⅵ) at high acidity.