[Background]: Nuclear radiation imaging relies on position-sensitive detectors

which generally require many channels of readout electronics. The traditional signals readout methods use a resistor-matrix network for the charge division

which significantly reduces the number of electronic channels

but the energy resolution degrades significantly. [Purpose]:This study aims to design a serial readout circuit that reduces the number of electronic channels while ensuring good energy resolution. [Methods]:The detector uses CsI (Tl) scintillators arranged in a 4 × 4 array and coupled with a SiPM array to generate current signals. After passing through a serial resistor network

the current signals are converted into the voltage signals through the charge-sensitive preamplifiers at both ends. Therefore

only two channels of readout electronics are required for single detector module

and the position of the detectors are identified using the amplitude ratio of the dual-end signals. [Results ]: The experimental results for 662 keV energy show that when the relative position resolution of the detector is 0.54%

the measured energy resolution can reach 6.51%.[Conclusions]: The serial readout circuit presented in this study offers an innovative solution for radiation imaging by reducing the number of required electronic channels and ensuring good energy resolution

potentially leading to more efficient and cost-effective imaging systems